Be aware that you can use the BASE command to specify the location in a drawing that will be used as its insertion point when you Insert or Xref it into another drawing.  It does not need to be 0,0 [though that is the default], but can be any location you choose.

 

One other effect of where you draw things in relation to 0,0 is that unless you specify otherwise, that is the location from which Hatch patterns are generated.  Hatch patterns that have elements at non-orthogonal angles or other complex characteristics can, depending on how many decimal places they go to in their definitions, have the relationships between elements get skewed as you get farther and farther from the origin.  That potential problem is avoided or at least lessened by keeping your drawing generally in the region close to 0,0.  But you can still overcome that if you need to be far from 0,0 by setting the SNAPBASE System Variable to a location in the middle of your content [even if only temporarily while you draw a Hatch, as you would anyway for some patterns where the positioning matters, such as brick coursing], and Hatch patterns will be generated from there.  In later versions, you can even designate the origin point for individual Hatch patterns within the drawing of them, or afterwards in the Hatch editor.