I use title blocks in layout space as part of my job and it would save huge amounts of time if the date changes and project number changes, etc. could be changed simultaneously on all layouts for that project.  In other words, if I could change the date on one title block and have it change on all other title blocks in files for that project.  Is this possible??

If they are attributes, try the command GATTE.

Sounds like you should be using Sheet Sets.

Using sheet sets is one possibility, but you don't have to go that way if you don't want to.  The solution will require modification of your layout template(s) and title block(s) however.  The first step is to go to DWGPROPS and the Custom tab and create some custom field names.  Use the Add button, name a field, and give it an initial value.  Once you've set up what you need include these fields in your title blocks.  Then when you want to change something common (ex. Proj Nos, Revision dates, Job Name, etc) all you have to do is reset the values one time via the Custom tab of
DWGPROPS.  Then a quick REGENALL will update all the values in the drawing file where ever they live. Give it a shot!Dave.

Because of file size and file naming issues at my workplace each drawing has to be a different file rather than different layouts on the same file. Will this work for different files if they are somehow "associated" digitally? Thanks again.

No.  Now you have crossed over into sheet sets territory.  The closest you might be able to get would be to create those custom fields then some sort of lisp routine or macro to update the values.  But you'd have to perform the action in each file individually unless the lisp was fairly complex.
 
You might want to scour the Lee Mac Programming site however to see if you can find something already built that would help you.   http://www.lee-mac.com/
 
Dave.heinsite2012-11-02 19:05:54