I have several files that will not publish because it says  "layout not initialized"
How do I fix this problem?

You will need to initialize (setup, define) the complaining layouts in AutoCAD.

I understand that, but that is what I am not sure how to do. Breeze1042008-03-20 22:22:49

In AutoCAD, just switch to the respective layout and use the PAGESETUP command. You need to define scale, page format, etc.

I have got several hundred files I have to do that to. 
 
Do you or any one know where to get a LISP or script file that I can automate the process with?

You can use e.g. Autodesk ScriptPro and run the following script on all your DWG files:
 
[CODE]VBAstmtFor Each Lay In ThisDrawing.Layouts: Lay.ConfigName = "None": Next Lay: ThisDrawing.Save[/CODE]

It says "Unknown command "[CODE]VBASTMT".  Press F1 for help."

I cannot see any "[CODE]" in the script from my posting - please use the exact text (starting with "VBASTMT...").

When I viewed it through my e-mail it looked like this...
 

[CODE]VBAstmtFor Each Lay In ThisDrawing.Layouts: Lay.ConfigName = "None": Next Lay: ThisDrawing.Save[/CODE]
I will try again with out the [CODE]